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KMID : 0614620100560020078
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Korean Journal of Gastroenterology
2010 Volume.56 No. 2 p.78 ~ p.82
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Study on Association between an H-RAS Gene Polymorphism and Gastric Cancer Development
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Song Hee-Jun
Pyun Jung-A
Lee Kwang-Jae
Cho Sung-Won
Kwack Kyu-Bum
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Abstract
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Background/Aims: Oncogenic RAS gene mutations have been frequently observed in many tumor types, and their associations with various cancers were reported. This study was conducted to evaluate the association between H-RAS T81C polymorphism and gastric cancer development.
Methods: H-RAS T81C polymorphism was genotyped in 321 chronic gastritis (ChG) and 151 gastric cancer (GC) patients using GoldenGate® Assay kit. Logistic regression analysis adjusted for age and gender was performed to identify the differences of genotype and allele distributions between the each group.
Results: All ChG and GC patients were in Hardy-Weinberg equilibrium. When the frequencies of H-RAS T81C genotype in each group were compared, the homozygous type of major allele TT was more frequent in GC group (62.9%) than ChG group (57.3%), while the frequencies of heterozygous type TC and homozygous type of minor allele CC were higher in ChG group than GC group (39.3% vs. 33.8%, 3.4% vs. 3.3%, respectively). In the results of logistic regression analyses adjusted for age and gender, the odds ratios were 0.845 (0.604-1.182), 0.799 (0.556-1.147), 0.741 (0.493-1.114) and 1.094 (0.366-3.270) for allele, codominant, dominant and recessive models, respectively. However, significant difference was not observed between two groups in any models.
Conclusions: H-RAS T81C polymorphism was not associated with gastric cancer development in a Korean population.
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KEYWORD
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Stomach neoplasm, Polymorphism, Genetic, H-RAS gene
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